• Int J Rheum Dis · Apr 2020

    Validity and reliability of Work Productivity and Activity Impairment among patients with axial spondyloarthritis in Singapore.

    • Jie Kie Phang, Yu Heng Kwan, Warren Fong, Chuen Seng Tan, Nai Lee Lui, Julian Thumboo, and Ying Ying Leung.
    • Department of Rheumatology and Immunology, Singapore General Hospital, Singapore.
    • Int J Rheum Dis. 2020 Apr 1; 23 (4): 520-525.

    ObjectivesTo assess the validity and reliability of the Work Productivity and Activity Impairment (WPAI) questionnaire in patients with axSpA.MethodsEnglish-speaking patients seen at a dedicated axSpA clinic in a Singapore tertiary referral hospital were recruited from 2017 to 2019. Content validity of the WPAI was assessed through cognitive debriefing interviews (CDIs). Construct validity was assessed by a priori hypotheses regarding the correlations of the WPAI outcomes (absenteeism, presenteeism, overall work productivity loss, and activity impairment) with Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Patient Global Score (BAS-G), patient global assessment (PGA) and pain scores. Known group validity was assessed relative to disease activity. Test-retest reliability was assessed by intraclass correlation coefficients (ICC) in patients without treatment change 2 weeks apart.ResultsCognitive debriefing interviews conducted with 10 patients (22-46 years old, 50% male) supported the content validity of the WPAI. We analyzed cross-sectional data from 168 patients (mean [SD] age 41.0 [14.4], 79.8% male). Construct validity was established by meeting 100% of the hypotheses. Presenteeism, overall work productivity loss, and activity impairment demonstrated strong correlations with BASFI, BAS-G, PGA, and pain (rs  > .6). The WPAI was able to distinguish patients grouped by disease activity. Test-retest reliability conducted with 50 patients ranged from moderate to good for all the four outcomes (absenteeism: ICC = 0.54; presenteeism: ICC = 0.76; activity impairment: ICC = 0.79; overall work productivity loss: ICC = 0.83; all P < .01).ConclusionsThis study supports the content validity, construct validity, and test-retest reliability of the WPAI in patients with axSpA.© 2020 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.

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