• A Nikolov, A Dimitrov, K Krŭsteva, and M Tsankova.
• Akush Ginekol (Sofiia). 2006 Jan 1; 45 (3): 16-9.

UnlabelledThe aim of this study is to determine the efficacy of the Misoprostol (Cytotec) in cases of abnormal and pathologic hypotonic hemorrhage in the early puerperium as a result of hypotonia of the uterus.Material And MethodsA group of 50 women with vaginal or abdominal labor developing hypotonic abnormal/pathologic bleeding after the placental delivery were given Misoprostol (Cytotec 200-400 microgr per rectum and/or per oral every 15 min). We compared this group with a control group without having postpartum bleeding.ResultsThe application of Misoprostol resulted in uterine contraction and discontinuing the abnormal bleedings in both vaginal and Caesarian deliveries. The main blood lost in the next two hours period after vaginal labor didn't differ with the blood lost of the normal labors (66 ml vs. 75 ml). In the Caesarian deliveries the blood lost after application of the Misoprostol also didn't differ with the blood lost after normal caesarian section (78 ml vs. 80 ml).ConclusionsMisoprostol decreases the hypotonic uterine bleedings in the placental and early puerperal period. The significance of the Misoprostol in the group of therapeutic events is determined by its fast therapeutic effect, its convenient application and its good tolerance.

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