• Internal medicine · May 2022

    Case Reports

    Chronic Infection with Hepatitis C Virus Subtype 1 g in a Japanese Patient Successfully Treated with Glecaprevir/Pibrentasvir.

    • Takeshi Hatanaka, Satoru Kakizaki, Takuya Kaburagi, Naoto Saito, Sachi Nakano, Yoichi Hazama, Sachiko Yoshida, Yoko Hachisu, Yoshiki Tanaka, Teruo Yoshinaga, Kenji Kashiwabara, Atsushi Naganuma, Yuichi Yamazaki, Toshio Uraoka, Shigeo Nagashima, Masaharu Takahashi, Tsutomu Nishizawa, Kazumoto Murata, and Hiroaki Okamoto.
    • Department of Gastroenterology, Gunma Saiseikai Maebashi Hospital, Japan.
    • Intern. Med. 2022 May 15; 61 (10): 1537-1543.

    AbstractA 66-year-old man, who had undergone plasma exchange 30 years previously in Egypt for the treatment of falciparum malaria, was referred to our hospital for treatment of chronic hepatitis C (HCV). An analysis of the 655-nucleotide 5'-untranslated region-core region sequence revealed infection with HCV subtype 1g. A phylogenetic analysis of the full-length HCV genome confirmed that the patient's HCV was subtype 1g, which was the first case identified in Japan. Although his HCV possessed several naturally occurring resistance-associated substitutions in the nonstructural (NS) 3 and NS5A regions, he was successfully treated by combination therapy with glecaprevir/pibrentasvir.

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