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- Noriyuki Miyaue, Akira Yoshida, Yuki Yamanishi, Satoshi Tada, Rina Ando, Yuko Hosokawa, Hayato Yabe, and Masahiro Nagai.
- Department of Clinical Pharmacology and Therapeutics, Ehime University Graduate School of Medicine, Japan.
- Intern. Med. 2022 Mar 1; 61 (5): 739-742.
AbstractVaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed and administered worldwide. There have been reports of neurological adverse events following immunization (AEFIs). We herein report a case of refractory longitudinally extensive transverse myelitis in a 75-year-old Japanese man following the first dose of the BNT162b2 vaccine. The patient developed total sensory loss below the umbilicus and complete paralysis in both legs. Although he was treated with steroid therapy and plasma exchange, his recovery was limited, and severe sequelae remained. Further studies, including large epidemiological studies, are required to understand the association between SARS-CoV-2 vaccines and neurological AEFI.
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