• Chen Hu, Yilin Fan, Shaoping Wu, Yu Zou, and Xiaosu Qu.
• Department of Encephalopathy, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China.
• Am J Emerg Med. 2021 Dec 1; 50: 784-788.

IntroductionIt is not well established to use vitamin D supplementation for migraine, and this meta-analysis aims to explore the efficacy of vitamin D for migraine patients.MethodsPubMed, EMbase, Web of science, EBSCO and Cochrane library databases were systematically searched up to May 2021, and we included randomized controlled trials (RCTs) exploring the effect of vitamin D for migraine patients.ResultsSix RCTs and 301 patients were included in the meta-analysis. Compared with control group in migraine patients, vitamin D supplementation could remarkably decrease headache attacks per month (MD = -2.74; 95% CI = -3.82 to -1.67; P < 0.00001), headache days per month (MD = -1.56; 95% CI = -2.44 to -0.68; P = 0.0005) and MIDAS score (MD = -5.72; 95% CI = -10.90 to -0.54; P = 0.03), but demonstrated no obvious influence on attack duration (MD = -2.20; 95% CI = -7.38 to 2.97; P = 0.40) or headache severity (MD = -0.56; 95% CI = -1.18 to 0.06; P = 0.08).ConclusionsVitamin D supplementation provided additional benefits to treat migraine.Copyright © 2021. Published by Elsevier Inc.

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