• Jonathan I Silverberg, Jin-Shei Lai, Paras P Vakharia, Kevin Patel, Vivek Singam, Rishi Chopra, Ryan Sacotte, Neha Patel, Supriya Rastogi, Robert Kantor, Derek Y Hsu, and David Cella.
• Department of Dermatology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois; Department of Medical Social Sciences, Feinberg School of Medicine at Northwestern University, Chicago, Illinois; Department of Preventive Medicine, Feinberg School of Medicine at Northwestern University, Chicago, Illinois; Northwestern Medicine Multidisciplinary Eczema Center, Chicago, Illinois; Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, DC. Electronic address: JonathanISilverberg@gmail.com.
• J. Am. Acad. Dermatol. 2020 May 1; 82 (5): 1174-1180.

BackgroundThe Patient-Reported Outcomes Measurement Information System (PROMIS) Itch Questionnaire (PIQ) was recently developed.ObjectiveTo validate PIQ short forms in adults with AD.MethodsSelf-administered questionnaires and skin examinations were performed in 239 adults with atopic dermatitis (AD) in a dermatology practice setting.ResultsPIQ items had good content validity. PIQ item bank T-scores strongly correlated with each other, moderately correlated with numeric and verbal rating scales for worst or average itch and with itch frequency, moderately to strongly correlated with patient-oriented eczema measure, and weakly to moderately correlated with the Eczema Area and Severity Index and Objective-Scoring AD (Spearman correlations, P < .0001). There were significant and stepwise increases of T-scores for all item banks with increasing patient-reported global severity (Wilcoxon rank sum test, P < .0001). However, there was limited ability to discriminate between the lowest or highest 2 levels of AD or itch severity. Item banks showed good internal consistency (Cronbach α, 0.91-0.95). No differential item functioning was identified by age, sex, race/ethnicity, or educational level. There were floor effects for total scores, particularly in almost clear/mild AD or itch.LimitationsSingle-center study.ConclusionsPIQ item bank short forms showed good content and construct validity and are feasible for potential use in clinical trials and practice.Copyright © 2019 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

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