• Dig Liver Dis · Dec 2017

    Symptoms of anxiety and depression are independently associated with inflammatory bowel disease-related disability.

    • Webber Chan, Hang Hock Shim, Miao Shan Lim, Fatimin Leila Bahjin Sawadjaan, Sangeetha Poongunam Isaac, Sai Wei Chuah, Rupert Leong, and Chris Kong.
    • Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore. Electronic address: webber.chan.p.w@singhealth.com.sg.
    • Dig Liver Dis. 2017 Dec 1; 49 (12): 1314-1319.

    BackgroundInflammatory bowel disease (IBD) frequently results in disability. The relevance of psychological effects in causing disability, and whether disability occurs similarly in non-Western cohorts is as yet unknown.AimWe assessed the relationship between symptoms of anxiety and depression, quality of life and disability in a Singaporean IBD cohort and their predictors.MethodsCross-sectional study. We assessed consecutive IBD subjects' IBD-Disability Index (IBD-DI), Hospital Anxiety and Depression Scale (HADS), and IBD questionnaire (IBDQ). Clinical and demographic variables were collected. Non-parametric statistical analyses were performed. Independent predictors of disability were identified through multivariate logistic regression.Results200 consecutive subjects were recruited (males: 69%; median age: 43.8 (±15.4) years; 95 had Crohn's disease (CD), 105 had ulcerative colitis (UC); median IBD duration: 10.8 (±9.0) years.) 27% of the cohort had anxiety and/or depression, which worsened disability (IBD-DI: -9 (±14) with anxiety vs 6 (±13) without anxiety, P<0.001; -12 (±16) with depression vs 5 (±13) without depression, P<0.001). Age at diagnosis, use of prednisolone, stricturing CD and active IBD were significant predictors of disability. IBDQ strongly correlated with IBD-DI(rs=0.82, P<0.01).ConclusionSymptoms of anxiety and depression were common in this Asian cohort of IBD and were strongly associated with IBD-related disability. Recognizing psychological issues contributing to disability in IBD is important to ensure holistic care and appropriate treatment.Copyright © 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

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