• Yang Huang, Hao Ren, Xiang Gao, Danyang Cai, Huajian Shan, Jinyu Bai, Lei Sheng, Yong Jin, and Xiaozhong Zhou.
• Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu.
• Spine. 2022 Sep 1; 47 (17): E570E578E570-E578.

Study DesignThe effect of amlodipine (AM) on spinal cord injury (SCI) and autophagy was researched by establishing ventral spinal cord cells (VSC4.1) oxygen and glucose deprivation model and SCI mice model.ObjectiveTo determine the neuroprotective effects of AM by upregulating autophagy during SCI repair.Summary Of Background DataAM, an antihypertensive medication, has been shown in several studies to inhibit neuronal apoptosis and exert neuroprotective effects in various central nervous system diseases. However, its effects on SCI are unexplored. Autophagy could inhibit cell apoptosis, which has been shown to promote SCI repair. However, the role of AM in autophagy remains unclear.MethodsWe examined the relationship between AM, apoptosis, and autophagy in ventral spinal cord cells and the injured spinal cords of C57BL/6 female mice respectively, following histological, behavioral, microscopic, immunofluorescence, and western blotting analyses.ResultsWe found that AM could inhibit motor neuronal apoptosis in vitro. Furthermore, AM promoted locomotor recovery by upregulating autophagy and alleviating apoptosis, neuronal loss, and spinal cord damage after SCI.ConclusionAM inhibited motoneuronal apoptosis by upregulating autophagy to improve SCI recovery.Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.

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