• Marta Araujo-Castro and Paola Parra-Ramírez.
• Unidad de Neuroendocrinología, Servicio de Endocrinología, Hospital Universitario Ramón y Cajal. Madrid & Instituto de Investigación Biomédica Ramón y Cajal (IRYCIS) & Departamento de Medicina, Universidad de Alcalá de Henares, Madrid, España. Electronic address: marta.araujo@salud.madrid.org.
• Med Clin (Barc). 2022 May 13; 158 (9): 424-430.

AbstractPrimary aldosteronism (PA) is the most common cause of secondary arterial hypertension. Moreover, it is associated with a higher cardio-metabolic risk than the observed in patients with essential arterial hypertension (EHT). Therefore, a high index of clinical suspicion for PA is mandatory. If an elevated aldosterone/renin ratio is confirmed, confirmatory tests should be performed, with the exception in those patients with florid PA, with, with spontaneous hypokalaemia, plasma aldosterone > 20 ng/dL and suppressed renin, in whom this step would not be strictly necessary. Intravenous saline infusion test or captopril test are the commonly used confirmatory tests. The last step in the diagnosis of PA is the localization study, being the computerized axial tomography (CT) of the adrenal glands the initial test of choice, and adrenal venous sampling (AVS), the definitive localization test in most cases. This review summarizes the available data about the diagnosis of PA, from screening to confirmatory study and localization.Copyright © 2021 Elsevier España, S.L.U. All rights reserved.

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