• Jun Young Ko, Mi Rim Lee, Eun-Hye Ha, and Aram Kim.
• Department of Rehabilitation Medicine, Myongji Hospital, 14-55 Hwasu-ro, Deokyang-gu, Goyang-si, Gyeonggi-do, Republic of Korea.
• Medicine (Baltimore). 2021 Nov 12; 100 (45): e27735e27735.

RationaleIn recent years, the use of extracorporeal membrane oxygenation (ECMO) treatment for pediatric patients with cardiorespiratory failure has increased, with emphasis being given to the prevention of complications in ECMO-treated patients. Several studies have reported ECMO-related central nervous system complications, such as intracranial hemorrhage, cerebral infarction, and seizure. However, few cases of peripheral nerve injury have been reported in ECMO-treated adults; there have also been no reported cases of peripheral nerve injury in the pediatric population.Patient ConcernsTwo pediatric patients aged 16 and 6 experienced motor weakness in the extremities after the insertion of ECMO equipment.DiagnosesThey were diagnosed with peripheral nerve injuries through an electrodiagnostic study that showed femoral/sciatic neuropathies and brachial plexopathy. Arteriography and doppler sonography was performed to find the cause of peripheral nerve injury, and this may be the results of vascular compromise and compressive injuries, respectively.InterventionsSurgical embolectomy was performed to remove thrombus in one patient. Two patients received orthosis, and physical therapy and occupational therapy were performed to prevent contracture and improve strength and functional use.OutcomesTwo pediatric patients showed a gradual improvement in motor power and function.LessonsThrough this case report, we present rare ECMO-related complications and emphasize the importance of early diagnosis and monitoring of peripheral nerve injury in ECMO-treated children.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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