• Xingzhen Lin, Manhua Zhu, Juan Yuan, Fang Zhi, and XinJu Hou.
• Nanchang Hongdu Hospital of Traditional Chinese Medicine, Nanchang, Jiangxi, Province, China.
• Medicine (Baltimore). 2021 Dec 17; 100 (50): e27994e27994.

RationaleThis report describes rehabilitation for a 53-year-old female recovering from non-healing skin and soft tissue defect after distal tibial open fracture by using platelet-rich fibrin topical repair following an automobile accident.Patient ConcernsThe patient was admitted to a rehabilitation specialty hospital approximately 1 year post a fracture of the distal left tibiofibula and separate surgical tibiofibular fracture incision and internal fixation + bone grafting.DiagnosesClinical presentation included the left ankle incision was interrupted for about 3 cm with poor healing, a small amount of muscle necrosis, fat liquefaction, a large amount of yellow purulent secretion overflow and necrotic material was seen in the local wound.InterventionsPlatelet rich fibrin (PRF) gel was injected into the wounds and submerged sites to make full contact with the wounds and close the wounds with the autologous platelet-rich fibrin prepared by mixing, and then covered with oil gauze to keep the wounds moist and promote granulation growth. The outermost layer was covered with cotton pads.OutcomesAfter 30 days of 2 PRF treatments, the skin defect was healed and no significant abnormality was observed at 6 months follow-up.LessonsTreatment with topical autologous platelet-rich plasma gel Significantly accelerates the healing of wounds, shortens healing time, improves healing quality and reduces scar formation without significant adverse effects.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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