• Andrzej Skręt, Joanna Trawińska, Joanna Bielatowicz, Mariusz Książek, Beata Niewęgłowska-Guzik, Andrzej Radkowski, Jaromir Kargol, Joanna Skręt- Magierło, Edyta Barnaś, and Bogusław Gawlik.
• Department of Obstetrics and Gynecology with Oncological Gynecology, Health Care Center, Krakowska 91, Dębica, Poland.
• Medicine (Baltimore). 2021 Dec 17; 100 (50): e28004.

RationaleGuidelines of rare synchronous tumours treatment are often unavailable due to lack of wide prospective studies. Additionally, their management is not just a simple sum of coexisting tumours management and has to regard many circumstances like symptoms, age, comorbidities, advancement.Patient ConcernsHerein, we report a case of an 81-year-old woman who presented with bleeding from the prolapsed uterus.DiagnosesBased on physical examination, that is, speculum examination, bimanual, and per rectum, followed by rectoscopy and histopathology, the diagnosis of cervical squamous cell carcinoma FIGO IIA2 in prolapsed uterus with anal canal adenocarcinoma cT1N0M0 was made.InterventionsDominating complaint of bleeding from prolapsed cervix was managed with radical vaginal hysterectomy in conjunction with wide colpectomy preceded by laparoscopic pelvic and paraaortic lymphadenectomy. Due to the lack of consent for removal of the anus, only radiotherapy was applied instead.OutcomesThe patient underwent magnetic resonance image follow-up. No recurrence was found at 18 months.LessonsImaging is useful method of synchronous cancers diagnostics. These cancers may vary in aetiology and stage. Cervical cancer may be co-existing with another anogenital cancer. Therapy of synchronous cancers should be individualized taking into account patient's consent, age, physical condition, and comorbidities.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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