• Yue Yang, Nan Li, and Guangwei Tian.
• Department of Pathology, the Third Affiliated Hospital of Jinzhou Medical University in Jinzhou, Liaoning, China.
• Medicine (Baltimore). 2021 Dec 17; 100 (50): e28149e28149.

BackgroundProstate tumor overexpressed-1 (PTOV1) was firstly depicted as gene and protein overexpressed in prostate cancers and preneoplastic lesions of high-grad intraepithelial neoplasia. Recently, people have paid recent attention to the oncogenic PTOV1 protein as a regulator with various cellular functions and pathways that tend to enhance cell growth and self-renewal in numerous cancer cell types. Its prognostic role in cancers remains controversial.MethodsEligible studies are identified by comprehensively searching literature in all available databases. The associations between PTOV1 expression and overall survival, disease-free survival, relapse-free survival, progression-free survival, and clinicopathological characteristics are estimated by employing hazard ratios and the confidence intervals of 95%. STATA 12.0 software was adopted to perform the meta-analysis.ResultsThis study will provide high-quality synthesis to evaluate the associations between PTOV1 expression and overall survival, disease-free survival /relapse-free survival , progression-free survival, and clinicopathological features.ConclusionThe study will provide updated evidence to assess whether the expression of PTOV1 is in association with poor prognosis in patients with cancers.Prospero Registration NumberCRD42020183853.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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