• Waail Rozi, Elrazi Awadelkarim Hamid Ali, Abdulrahman F Al-Mashdali, Mohamed Abdelrazek, and Mohamed A Yassin.
• Internal Medicine, Hamad Medical Corporation, Doha, Qatar.
• Medicine (Baltimore). 2021 Dec 23; 100 (51): e27988e27988.

IntroductionSickle cell disease (SCD) is a hematological disorder characterized by sickling of red blood cells. Patients are at increased risk of venous thromboembolism. There are no guidelines for the management of venous thromboembolism in sickle cell disease specifically in terms of the anticoagulant of choice.Patient ConcernsHere, we report a case of a 30-year-old lady with past medical history of sickle cell disease who came with chest pain and shortness of breath.DiagnosisWe found that she has bilateral pulmonary embolism (PE).InterventionShe was started on rivaroxaban.OutcomeThe patient was followed for 18 months, she did not suffer from recurrence of PE, and she did not develop any complications related to rivaroxaban.ConclusionWe concluded that rivaroxaban is effective in treating PE in sicklers and also it is safe.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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