• Mustafa Abdul Karim, Nadeen Al-Baz, Peter M Haddad, Shuja M Reagu, and Majid Alabdulla.
• Department of Psychiatry, Hamad Medical Corporation, Doha, Qatar.
• Medicine (Baltimore). 2021 Dec 23; 100 (51): e28003e28003.

RationaleIrritable bowel syndrome (IBS) is a chronic and debilitating functional disorder of the gastrointestinal tract manifested by abdominal pain and bowel habit dysregulation. The pathophysiology is complex and management targets symptom resolution. Therapeutic interventions range from dietary modification, psychological interventions, exercise, to the use of antispasmodics, antibiotics, and antidepressants. Anecdotal reports have suggested that buspirone may be beneficial in the treatment of functional dyspepsia and IBS and its physiological effect of reducing gastric tone provides a rational for its benefit.Patient ConcernsA 28-year-old man with unremarkable past medical and psychiatric history presented with worsening abdominal pain, bloating, and bowel movement dysregulation of over 6-year duration.DiagnosesPhysical examination revealed mild distension and discomfort on deep palpation. Thorough blood investigations, stool analysis and culture, and imaging were unremarkable except for the detection of mucus with stool. The patient was diagnosed with irritable bowel syndrome with mixed habits.InterventionsDietary adjustment and a range of medications (mebeverine, simethicone, loperamide, rifaximin, sertraline and amitriptyline) yielded unsatisfactory response of were not tolerated. Buspirone was eventually introduced.OutcomesBuspirone was associated with a significant and sustained improvement in IBS symptoms and quality of life.LessonsThis case suggests that buspirone was effective in treating refractory IBS. Further research is needed to assess the role of buspirone in IBS management.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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