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- Yuan Ma, Kewei Sun, Jianzhong Cao, Xiaowu Qin, Jiaoling Shi, Huiying Li, Jun Zhang, and Tao Zhang.
- Graduate School, Hunan University of Chinese Medicine, China.
- Medicine (Baltimore). 2021 Dec 23; 100 (51): e28083e28083.
BackgroundNon-alcoholic fatty liver disease (NAFLD) is a global health burden. However, there are no approved drugs for NAFLD. A number of studies have shown that acupuncture combined with Chinese herbal medicine (CHM) can be beneficial for NAFLD. However, high-quality trials are still lacking. Therefore, we aimed to conduct a systematic review and meta-analysis to assess the effectiveness and safety of acupuncture combined with CHM for NAFLD.MethodsEight electronic databases including PubMed, the Cochrane Library, Web of Science, EMBASE, China National Knowledge Infrastructure, Chinese Scientific and Technical Journals Database, and Wan-fang Database from inception to November 2021 will be searched. We will also search for Clinical Trials Registry Platforms as a supplement. Randomized controlled trials on acupuncture combined with CHM for NAFLD will be included. Literature screening, data extraction, and risk of bias assessment were independently conducted by 2 reviewers. All differences between the 2 reviewers will be discussed and resolved by a third reviewer. Revman5.3 software will be used for meta-analysis.ResultThis study aimed to evaluate the effectiveness and safety of acupuncture combined with CHM for NAFLD.ConclusionThe findings of this study will provide more evidence to determine whether acupuncture combined with CHM for NAFLD is an effective and safe intervention for NAFLD.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
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