• Li Liu, Liang-An Zhou, and Ya-Lei Sun.
• Department of Chinese Medicine, Jiaxing Maternity and Child Health Care Hospital, No. 2468 of Central East Road, Nanhu District, Jiaxing, Zhejiang, China.
• Medicine (Baltimore). 2021 Dec 23; 100 (51): e28190e28190.

BackgroundThe tic disorders are common neuropsychiatric disorders that affects the growth and development of children and adolescents. Chinese herbal medicine is commonly used for the treatment of tic disorders. However, there is no consensus on the difference in clinical efficacy compared with routine treatment. Therefore, we plan to perform a systematic review and meta-analysis to review the clinical efficacy of Chinese herbal medicine for tic disorders.MethodsCochrane Central Register of Controlled Trials, PubMed, EMBASE, Chinese National Knowledge Infrastructure, Chinese Bio-medical Database, and Wanfang database will be searched from their inception until March 31, 2021. The meta-analysis will be conducted with Review Manager 5.3 software to systematically review the clinical efficacy and safety of Chinese herbal medicine for tic disorders. The primary outcome will include the improvement rate (amount) of tic symptoms using related scales or methods, and the secondary outcome will include adverse events.ResultsThis analysis will provide useful information about clinical efficacy and safety of Chinese herbal medicine for tic disorders.ConclusionsOur study will generate strong evidence of Chinese herbal medicine for patients with tic disorders and provide suggestions for clinical practice.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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