• Yuan Zhuang, Shushan Zhang, Yao Liu, and Hua Yang.
• Department of Gynecology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
• Medicine (Baltimore). 2021 Dec 23; 100 (51): e28343e28343.

IntroductionThe optimal management of recurrent ovarian granulosa cell tumors is still unknown, and hormone therapy may be an alternative for chemotherapy-resistant cases.Patient ConcernsA 46-year-old woman presented with a third recurrence after primary treatment of granulosa cell tumors. She developed tumor progression and drug-induced nephritis after 6 cycles of combined treatment with cisplatin and paclitaxel for the second recurrence and failed to benefit from chemotherapy, after the third optimal cytoreduction and tumor progression after 6 months of letrozole treatment.DiagnosisLetrozole-resistant recurrent ovarian granulosa cell tumors.InterventionsIntramuscular Diphereline 3.75 mg q28d.OutcomesComputed tomography showed the metastatic neoplasm resolved. Progression-free survival is 20 months.ConclusionHormone therapy may be an alternative to treat recurrent granulosa cell tumors, and gonadotropin-releasing hormone agonists may be a rescue treatment for aromatase inhibitor-resistant cases.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

18 keywords...

hide…