• Masui · Sep 2006

    Randomized Controlled Trial Multicenter Study Comparative Study

    [Neuromuscular blocking effects of Org 9426 (rocuronium bromide); a comparative study with vecuronium bromide in Japanese patients].

    • Koh Shingu, Munehiro Masuzawa, Keiichi Omote, Akiyoshi Namiki, Hirosato Kikuchi, Miwako Kawamada, Shigehito Sato, Tomomasa Kimura, Norio Hatano, Hideki Nakatsuka, Kiyoshi Morita, Tetsuya Hara, Yuichi Kanmura, and Junzo Takeda.
    • Department of Anesthesiology, Kansai Medical University, Moriguchi.
    • Masui. 2006 Sep 1;55(9):1140-8.

    BackgroundEfficacy and safety of Org 9426 were compared with those of vecuronium bromide in Japanese patients.MethodsWe studied 88 Japanese patients undergoing surgery requiring general anesthesia. Patients were allocated randomly to receive intubation dose of 0.6 mg x kg(-1), 0.9 mg x kg(-1) of Org 9426 or 0.1mg x kg(-1) of vecuronium. Following an intubation dose, patients received maintenance doses of 0.1, 0.15 or 0.2 mg x kg(-1) of Org 9426 or 0.025 mg x kg(-1) of vecuronium. The neuromuscular block was monitored with acceleromyography using TOF stimuli. Sevoflurane was administered to all treatment groups after intubation.ResultsThe onset times of the 0.6 and 0.9 mg x kg(-1) of Org 9426 groups were 84.6 and 77.1 sec respectively, which showed statistical difference between the onset time of 0.1 mg x kg(-1) of vecuronium, 125.7 sec. The intubation condition was similar among three treatment groups. The clinical durations of 0.6 and 0.9 mg x kg(-1) of Org 9426 and 0.1 mg x kg(-1) of vecuronium were 53.4, 73.4 and 59.9 min, respectively. Clinical duration and spontaneous recovery time of maintenance dose of 0.15 mg x kg(-1) of Org 9426 were similar to those of 0.025 mg x kg(-1) of vecuronium.ConclusionsOrg 9426 showed more rapid onset time than that of vecuronium and similar clinical duration and recovery times to those of vecuronium in Japanese patients.

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