• Rev Esp Anestesiol Reanim · Feb 2010

    Review

    [Sugammadex, a novel drug for neuromuscular blockade reversal].

    • L A Fernández Meré and M Alvarez-Blanco.
    • Servicio de Anestesiología, Reanimación y Terapéutica del Dolor, Hospital Universitario Central de Asturias (HUCA), Centro Covadonga, Oviedo, Principado de Asturias. lafmere@teleline.es
    • Rev Esp Anestesiol Reanim. 2010 Feb 1;57(2):95-102.

    AbstractSignificant progress in the management of aminosteroid nondepolarizing neuromuscular blockers will follow the introduction of sugammadex (Org 25969). Safety and rapid recovery of muscle force will improve and the adverse effects of acetylcholinesterase inhibitors will be avoided. Sugammadex is a modified gamma-cyclodextrin agent developed for the specific reversal of rocuronium and, to a lesser extent, vecuronium. This novel drug functions by means of encapsulation (chelation). Sugammadex was recently approved by the European Medicines Evaluation Agency and became available in Spain in 2009, leading to a series of changes related to patient safety and surgical conditions. We review the literature on sugammadex published to date.

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