• Critical care medicine · Aug 2013

    Review

    In silico modeling: methods and applications to trauma and sepsis.

    • Yoram Vodovotz and Timothy R Billiar.
    • Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA. vodovotzy@upmc.edu
    • Crit. Care Med.. 2013 Aug 1;41(8):2008-14.

    ObjectivesTo familiarize clinicians with advances in computational disease modeling applied to trauma and sepsis.Data SourcesPubMed search and review of relevant medical literature.SummaryDefinitions, key methods, and applications of computational modeling to trauma and sepsis are reviewed.ConclusionsComputational modeling of inflammation and organ dysfunction at the cellular, organ, whole-organism, and population levels has suggested a positive feedback cycle of inflammation → damage → inflammation that manifests via organ-specific inflammatory switching networks. This structure may manifest as multicompartment "tipping points" that drive multiple organ dysfunction. This process may be amenable to rational inflammation reprogramming.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…