• World Neurosurg · Jan 2022

    Review

    Challenges in the Development of Biological Approaches for the Treatment of Degenerative Disc Disease.

    • Jacob L Goldberg, Andrew Garton, Sunidhi Singh, Sertac Kirnaz, Fabian Sommer, Joseph A Carnevale, Basar Atalay, Branden Medary, Lynn B McGrath, and Roger Härtl.
    • Department of Neurological Surgery, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, New York, USA.
    • World Neurosurg. 2022 Jan 1; 157: 274-281.

    AbstractThere are numerous innovative and promising approaches aimed at slowing, reversing, or healing degenerative disc disease. However, multiple treatment-specific impediments slow progress toward realizing the benefits of these therapies. First, the exact pathophysiology underlying degenerative disc disease remains complicated and challenging to study. In addition, the study of the spine and intervertebral disc in animal models is difficult to translate to humans, hindering the utility of preclinical research. Biological treatments are subject to the complex biomechanical environment in which native discs degenerate. The regulatory approval environment for these therapeutics will likely involve a high degree of scrutiny. Finally, patient selection and assessment of outcomes are a particular challenge in this clinical setting.Copyright © 2021 Elsevier Inc. All rights reserved.

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