• Jaime B Hyman, Evan S Leibner, Pranai Tandon, Natalia N Egorova, Adel Bassily-Marcus, Roopa Kohli-Seth, Varun Arvind, Helena L Chang, Hung-Mo Lin, and Matthew A Levin.
• Department of Anesthesiology, Yale University School of Medicine, New Haven, CT.
• Crit Care Explor. 2020 Oct 1; 2 (10): e0254.

ObjectivesTo examine whether increasing time between admission and intubation was associated with mortality in patients with coronavirus disease 2019 who underwent mechanical ventilation.DesignRetrospective cohort study of patients with severe acute respiratory syndrome coronavirus 2 infection who were admitted between January 30, 2020, and April 30, 2020, and underwent intubation and mechanical ventilation prior to May 1, 2020. Patients were followed up through August 15, 2020.SettingFive hospitals within the Mount Sinai Health System in New York City, NY.PatientsAdult patients with severe acute respiratory syndrome coronavirus 2 infection who underwent intubation and mechanical ventilation.InterventionsTracheal intubation and mechanical ventilation.Measurements And Main ResultsThe primary outcome was in-hospital mortality. A hospital-stratified time-varying Cox model was used to evaluate the effect of time from admission to intubation on in-hospital death. A total of 755 adult patients out of 5,843 admitted with confirmed severe acute respiratory syndrome coronavirus 2 infection underwent tracheal intubation and mechanical ventilation during the study period. The median age of patients was 65 years (interquartile range, 56-72 yr) and 64% were male. As of the time of follow-up, 121 patients (16%) who were intubated and mechanically ventilated had been discharged home, 512 (68%) had died, 113 (15%) had been discharged to a skilled nursing facility, and 9 (1%) remained in the hospital. The median time from admission to intubation was 2.3 days (interquartile range, 0.6-6.3 d). Each additional day between hospital admission and intubation was significantly associated with higher in-hospital death (adjusted hazard ratio, 1.03; 95% CI, 1.01-1.05).ConclusionsAmong patients with coronavirus disease 2019 who were intubated and mechanically ventilated, intubation earlier in the course of hospital admission may be associated with improved survival.Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.

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