• Imad Abboud, Corinne Antoine, François Gaudez, Fabienne Fieux, Carmen Lefaucheur, Evangéline Pillebout, Denis Viglietti, Tomas Serrato, Jérôme Vérine, Martin Flamant, Marie-Noëlle Peraldi, and Denis Glotz.... more less
• Nephrology and Transplantation, Saint Louis Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France. imad.abboud@sls.aphp.fr
• Int J Artif Organs. 2011 Jun 1; 34 (6): 513-8.

PurposeExpanded criteria donors (ECD) kidneys are a potential solution to organ shortage, but exhibit more delayed graft function (DGF). We conducted a prospective controlled study aiming to evaluate the impact of pulsatile perfusion preservation (PPP) on DGF rate.MethodsInclusion criteria were: 1) ECD definition (any brain-dead donor aged > 60 years or aged 50-60 years with at least 2 of the following: history of hypertension, terminal serum creatinin level = 1.5 mg/dL, death resulting from a cerebrovascular accident; 2) Donor prolonged circulatory arrest (> 20 mn); 3) previsible cold ischemia time longer than 24 hours. In each pair of kidneys, one organ was preserved with PPP and the other organ was preserved in static cold storage.ResultsFrom February 2007 to September 2009, a total of 22 donors (44 recipients) were included. Recipients were comparable in the two groups with respect to demographic and immunological data. The rate of DGF was significantly lower (9% vs. 31.8%, p = 0.021) in the PPP group. At 1, 3, and 12 months, renal function was comparable in the two groups.ConclusionsPulsatile perfusion preservation significantly reduced DGF rate in ECD kidney transplantation.

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