• Sihua Che, Meiling Wang, Le Liu, Shumao Zhang, and Guijun Shi.
• School of Traditional Chinese Medicine, Changchun University of Traditional Chinese Medicine, Changchun, China.
• Medicine (Baltimore). 2021 Dec 30; 100 (52): e28447e28447.

BackgroundCoronary heart disease (CHD) is considered one of the major causes of morbidity and mortality worldwide, posing a serious threat to public health. Current therapeutic approaches for CHD mainly focus on drug therapy, coronary artery bypass grafting, and percutaneous coronary intervention. However, there still exist some problems including drug side effects, adverse cardiac events after percutaneous coronary intervention. Guhong injection is a compound preparation of traditional Chinese medicine and western medicine. Several clinical studies have shown that Guhong injection can effectively relieve the clinical symptoms of CHD patients and improve clinical efficacy. However, there is no systematic review to evaluate the effectiveness and safety of Guhong injection in treating CHD. Therefore, in this study we will plan to systematic review to evaluate the effectiveness and safety of Guhong injection for CHD, providing a strong evidence-based medical reference for clinical use.MethodsThe database search includes EMBASE, PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure, WanFang Database, Chinese Biomedical Database, Chinese Scientific Journal Database. The retrieval time was from their inception to November 30, 2021. The main outcome indicators include the frequency, severity, and duration of angina pectoris attacks, electrocardiogram changes, and dose of nitroglycerin. The analysis software uses RevMan 5.3.ResultsBy collecting the existing evidence, the results of this study will systematically evaluate the effects of Guhong injection in the treatment of CHD.ConclusionThe results of this study will provide evidence for the efficacy and safety of Guhong injection in the treatment of CHD.Inplasy Registration NumberINPLASY2021120032.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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