• Expert Rev Anticancer Ther · Jan 2016

    Comparative Study

    Nivolumab for advanced non-small cell lung cancer: an evaluation of a phase III study.

    • Ruxandra Ulmeanu, Ileana Antohe, Ecaterina Anisie, and Sabina Antoniu.
    • a Marius Nasta Institute , Bucuresti , Romania.
    • Expert Rev Anticancer Ther. 2016 Jan 1; 16 (2): 165-7.

    AbstractLung cancer still remains associated with a high mortality rate and more efficacious therapies are needed in order to improve the disease outcome. Nivolumab is a monoclonal antibody which blocks the programmed death-1 receptor which is currently evaluated in phase III clinical trials in advanced lung cancer. Here, we evaluate the results of a phase III study in which nivolumab efficacy and safety were compared to those of docetaxel. Nivolumab was able to improve survival and progression-free survival and exhibited a very good safety profile. Further clinical data are needed in order to better position this therapy among the existing methods. The promising results support the use of this therapy as a stand-alone approach.

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