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Kidney international · Apr 2006
CommentArteriolar remodeling in essential hypertension: are connective tissue growth factor and transforming growth factor involved?
- B Rodriguez-Iturbe.
- Hospital Universitario and Universidad del Zulia, Maracaibo, Venezuela. bernardori@telcel.net.ve
- Kidney Int. 2006 Apr 1; 69 (7): 1104-5.
AbstractGómez-Garre et al. report increased expression of connective tissue growth factor and transforming growth factor-beta and worsening of remodeling in subcutaneous arterioles of patients with essential hypertension during amlodipine treatment. Losartan improves remodeling without changes in cytokine expression. The discordant effects of two well-accepted treatments for hypertension underline the need for further studies on therapy-induced changes in arteriolar remodeling.
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