• Mehrman Chalaki, Luis J Cruz, Sabien G A van Neerven, Joost Verhaagen, Albert Dahan, and MalessyMartijn J AMJAthe Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands..
• Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands; the Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands.
• Anesthesiology. 2022 Feb 1; 136 (2): 362-388.

AbstractThe dorsal root ganglion is widely recognized as a potential target to treat chronic pain. A fundamental understanding of quantitative molecular and genomic changes during the late phase of pain is therefore indispensable. The authors performed a systematic literature review on injury-induced pain in rodent dorsal root ganglions at minimally 3 weeks after injury. So far, slightly more than 300 molecules were quantified on the protein or messenger RNA level, of which about 60 were in more than one study. Only nine individual sequencing studies were performed in which the most up- or downregulated genes varied due to heterogeneity in study design. Neuropeptide Y and galanin were found to be consistently upregulated on both the gene and protein levels. The current knowledge regarding molecular changes in the dorsal root ganglion during the late phase of pain is limited. General conclusions are difficult to draw, making it hard to select specific molecules as a focus for treatment.Copyright © 2021, the American Society of Anesthesiologists. All Rights Reserved.

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