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- Doo Sun Sim, Myung Ho Jeong, Dae Sung Park, Jung Ha Kim, Kyung Seob Lim, In Ho Bae, Piao Zhehao, Hae Young Yang, Je Hoon Lee, Dae Young Hyun, Young Joon Hong, Ju Han Kim, Youngkeun Ahn, and Jung Chaee Kang.
- Heart Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Republic of Korea; Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Republic of Korea; Korea Cardiovascular Stent Institute, Jangseong, Republic of Korea.
- Int. J. Cardiol. 2016 Nov 1; 222: 436-440.
BackgroundTitanium dioxide (TiO2) films have superior biocompatibility and may be effective as drug-binding matrices for drug-eluting stents (DESs). We sought to evaluate efficacy of a polymer-free DES coated with everolimus using nitrogen-doped TiO2 film deposition in a porcine coronary restenosis model.MethodsForty coronary arteries in 20 pigs were randomly allocated to group 1 (bare-metal stents (BMSs), 3.0×18mm, n=10), group 2 (BMSs with nitrogen-doped TiO2 film deposition, 3.0×18mm, n=10), group 3 [commercial everolimus-eluting stent, 3.0×18mm, n=10], and group 4 (polymer-free everolimus-eluting stent using nitrogen-doped TiO2 film deposition, 3.0×18mm, n=10). Stents were randomly implanted in the left anterior descending coronary artery and left circumflex artery with stent:artery ratio of 1.3. Four weeks later, pigs underwent follow-up coronary angiography and were sacrificed for histopathologic analysis.ResultsPercent area stenosis was greater in group 1 compared to groups 3 and 4 (46.4±13.8% vs. 30.2±11.7% vs. 29.2±8.9%, respectively, p=0.005). Fibrin score was lower in groups 1 and 2, compared to groups 3 and 4: 0.87±0.67 vs. 0.76±0.61 vs. 2.27±0.24 vs. 1.75±0.31, respectively, p<0.001). Injury score and inflammation score were not different. Comparison between DES showed a higher fibrin score in group 3 than group 4 (2.27±0.24 vs. 1.75±0.31, p=0.023).ConclusionsIn a porcine model of coronary restenosis, a novel polymer-free DES using nitrogen-doped TiO2 film deposition shows higher biocompatibility and compares favorably with a commercial DES.Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
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