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- M Menges and T Hoehler.
- Innere Medizin II, Medizinische Klinik und Poliklinik, Universitätskliniken des Saarlandes, Homburg, Germany. inmmen@uniklinik-saarland.de
- Onkologie. 2004 Feb 1; 27 (1): 47-53.
AbstractThe results of the standard therapy of upper gastrointestinal tract cancer remain unsatisfactory, mainly because still the majority of cases are diagnosed at a late stage of disease, which implicates a poor prognosis. Innovative strategies focus on neoadjuvant chemotherapy in locally advanced gastric cancer and chemo- or radiochemotherapy in advanced oesophageal cancer. Results of phase II studies published so far have been promising. There is rising evidence that adjuvant radiochemotherapy in gastric cancer may be of benefit for curatively resected patients, whereas the results of trials including a systematic lymphadenectomy have to be awaited. New substances like the taxanes or irinotecan in the palliative setting did not prove to be superior to platinum-based standard chemotherapy protocols so far.Copyright 2004 S. Karger GmbH, Freiburg
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