• Shahram Ala, Majid Saeedi, Fariborz Eshghi, and Parastou Mirzabeygi.
• Faculty of Pharmacy, Clinical Pharmacy, Mazandaran University of Medical Sciences, P.O. Box 48175-861, Sari, Mazandaran Province, Iran. sh204ala@yahoo.com
• Dis. Colon Rectum. 2008 Feb 1; 51 (2): 235-8.

BackgroundTopical metronidazole (10 percent) has been previously demonstrated to decrease postoperative pain after hemorrhoidectomy. The aim of this study was to evaluate the effect of topical metronidazole (10 percent) in reducing postoperative and after-defecation pain of hemorrhoidectomy.Materials And MethodsA double-blind, randomized trial was conducted to compare posthemorrhoidectomy pain with use of topical metronidazole (10 percent) vs. placebo carrier, applied to surgical site. Forty-seven patients were randomly allocated to receive metronidazole (n=25) or placebo (n=22). Pain was assessed using a visual analog scale preoperatively and on postoperative hours 6 and 12 and at days 1, 2, 7, and 14. The use of narcotic, additional analgesics, and complications were recorded. (Pain scores were calculated and compared with baseline values and control group (t test, SPSS ver.10).ResultsPatients in the topical metronidazole group had significantly less postoperative pain than those in the placebo group up to day 14 (P ConclusionThese finding indicate that topical 10 percent metronidazole significantly reduce posthemorrhoidectomy discomfort, and postoperative defecation pain is reduced compared with that of the placebo control group.

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