• Koen Ameloot, Katrijn Van De Vijver, Ole Broch, Niels Van Regenmortel, Inneke De Laet, Karen Schoonheydt, Hilde Dits, Berthold Bein, and Manu L N G Malbrain.
• Department of Intensive Care Medicine, Ziekenhuis Netwerk Antwerpen, ZNA Stuivenberg, Lange Beeldekensstraat 267, 2060 Antwerp, Belgium.
• ScientificWorldJournal. 2013 Jan 1;2013:519080.

IntroductionNexfin (Bmeye, Amsterdam, Netherlands) is a noninvasive cardiac output (CO) monitor based on finger arterial pulse contour analysis. The aim of this study was to validate Nexfin CO (NexCO) against thermodilution (TDCO) and pulse contour CO (CCO) by PiCCO (Pulsion Medical Systems, Munich, Germany).Patients And MethodsIn a mix of critically ill patients (n = 45), NexCO and CCO were measured continuously and recorded at 2-hour intervals during the 8-hour study period. TDCO was measured at 0-4-8 hrs.ResultsNexCO showed a moderate to good (significant) correlation with TDCO (R (2) 0.68, P < 0.001) and CCO (R (2) 0.71, P < 0.001). Bland and Altman analysis comparing NexCO with TDCO revealed a bias (± limits of agreement, LA) of 0.4 ± 2.32 L/min (with 36% error) while analysis comparing NexCO with CCO showed a bias (±LA) of 0.2 ± 2.32 L/min (37% error). NexCO is able to follow changes in TDCO and CCO during the same time interval (level of concordance 89.3% and 81%). Finally, polar plot analysis showed that trending capabilities were acceptable when changes in NexCO (ΔNexCO) were compared to ΔTDCO and ΔCCO (resp., 89% and 88.9% of changes were within the level of 10% limits of agreement).Conclusionwe found a moderate to good correlation between CO measurements obtained with Nexfin and PiCCO.

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