• Richard L Wasserman, Angela R Hague, Deanna M Pence, Robert W Sugerman, Stacy K Silvers, Joanna G Rolen, and Morley Herbert.
• Allergy Partners of North Texas, Dallas, Texas; Medical City Children's Hospital, Dallas, Texas. Electronic address: drrichwasserman@gmail.com.
• J Allergy Clin Immunol Pract. 2019 Feb 1; 7 (2): 418-426.e4.

BackgroundPeanut allergy (PA) is a significant and increasing problem, interfering with psychological development and family life. The standard recommendation to avoid peanut products and have access to injectable epinephrine is often inadequate. Oral immunotherapy for PA has been formally studied. Clinical observations of allergen immunotherapy have repeatedly enhanced patient care.ObjectiveThe purpose of this study was to report observations on the treatment of 270 patients with PA over 8.5 years.MethodsThis is a retrospective record review of patients beginning peanut oral immunotherapy between January 1, 2009, and June 1, 2017, approved by the North Texas Institutional Review Board.ResultsA total of 270 patients aged 4 to 18 years comprising 107 girls and 163 boys were treated. A total of 214 of 270 patients (79%) completed immunotherapy escalation. Age (P < .001) and peanut IgE (P < .001) correlate inversely with completing dose escalation. Epinephrine-treated reactions in 63 and isolated gastrointestinal symptoms in 101 patients, respectively, were the most common adverse reactions to treatment but did not preclude success. Peanut IgE decreased by 65% after 3 years of maintenance treatment and 14 of 214 patients (6.5%) were able to achieve sustained unresponsiveness.ConclusionsIn an allergy office practice setting, 79% of patients are able to complete a peanut desensitization protocol and maintain the desensitized state indefinitely with daily dosing. With appropriate planning and precautions, peanut oral immunotherapy may be performed in an allergy office. Careful observations of clinical treatment can contribute to the development of effective treatment strategies.Copyright © 2018 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

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