• Abdulkadir Demir, Mahmut Çamlar, Gökçe Ceren Kuşçu, Çevik Gürel, Fatih Oltulu, Merve Oren, Ceyda Aldağ, Nefise Ülkü Karabay Yavaşoğlu, Evren Sandal, and Füsun Özer.
• Department of Neurosurgery, Adıyaman University Training and Research Hospital, Adıyaman, Turkey.
• World Neurosurg. 2022 Apr 1; 160: e55-e60.

BackgroundCentral nervous system infection after neurosurgical procedures is a severe complication with high morbidity rates and sometimes mortality. Our experimental study aimed to investigate the biochemical and histopathologic effects of vancomycin on neural tissues when applied to the cisterna magna.MethodsWistar albino rats were randomly divided into 4 groups: Control (Group 1) and different vancomycin dose groups (Groups 2, 3, and 4). In Group 1, 0.1 mL cerebrospinal fluid was drained from the cisterna magna and 0.1 mL 0.9% NaCI (normal saline) was administered into the subarachnoid space. In the study groups, 0.1 mL cerebrospinal fluid was drained from the cisterna magna and 0.1 mg/200g rat per day (Group 2), 0.2 mg/200g rat per day (Group 3), and 0.4 mg/200g rat per day (Group 4) vancomycin were administered into the subarachnoid space for 7 days. All rats were sacrificed on the eighth day. Serum superoxide dismutase and catalase levels were measured. Histopathologic and immunohistochemical analyses were conducted.ResultsThe findings showed that the administration of 0.2 and 0.4 mg/kg doses had significant differences in superoxide dismutase and catalase activity compared with the controls (P < 0.05). These vancomycin doses also induced the apoptotic process, and the enzyme activity results correlated with immunohistochemical results.ConclusionsDose-related neurotoxicity of intrathecal vancomycin was shown at the cellular level. The importance of dose regulation of intrathecal vancomycin has come into view. To our knowledge, this is the first study in the literature that has investigated the neurotoxic effects of vancomycin.Copyright © 2021 Elsevier Inc. All rights reserved.

11 keywords...

hide…