-
- D Corbett.
- Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.
- Neuroreport. 1991 Dec 1; 2 (12): 805-8.
AbstractIntracranial self-stimulation (ICSS) of at least some brain sites is thought to be mediated by mesolimbic dopamine (DA) neurons. However other ICSS sites, especially those in the medial prefrontal cortex (MFC), have been shown to be relatively insensitive to drugs (e.g. amphetamine, neuroleptics) that alter DA synaptic transmission. In the present study, rats with ICSS electrodes implanted in both the medial forebrain bundle (MFB) and the MFC were treated once per day for 10 days with cocaine (15.0 mg kg-1). Cocaine decreased the thresholds for both MFB (-51.4%) and MFC (-23.0%) ICSS. Cocaine also increased rates of responding for MFC but not MFB ICSS. These data provide additional support for the view that the MFC contributes to the rewarding effects of cocaine.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..