• Expert review of vaccines · Jan 2015

    Review

    Strategic development of the conserved region of the M protein and other candidates as vaccines to prevent infection with group A streptococci.

    • Michael F Good, Manisha Pandey, Michael R Batzloff, and Gregory J Tyrrell.
    • a 1 Institute for Glycomics, Griffith University, Gold Coast, Australia.
    • Expert Rev Vaccines. 2015 Jan 1; 14 (11): 1459-70.

    AbstractGroup A streptococcal (Streptococcus pyogenes) diseases remain a major public health problem in developing countries as well as in the indigenous populations of developed countries. In view of the large number of Group A streptococcal infections and the potential for sequelae such as rheumatic heart disease, control strategies including the development of an anti-streptococcal vaccine that is able to prevent infection and colonization is important. In this article, we discuss the epidemiology and strain variability of Group A streptococcus and how this is rendering vaccine development more challenging. We discuss vaccine strategies with a focus on the conserved region of the M protein and present a viewpoint for the impediments and the way forward.

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