• Giulia Brisotto, Elena Muraro, Marcella Montico, Chiara Corso, Chiara Evangelista, Mariateresa Casarotto, Cristina Caffau, Roberto Vettori, Maria Rita Cozzi, Stefania Zanussi, Matteo Turetta, Federico Ronchese, and Agostino Steffan.
• Immunopathology and Cancer Biomarkers Units, Department of Translational Research, CRO Aviano, National Cancer Institute, IRCCS, 33081 Aviano, PN, Italy.
• Clin. Chim. Acta. 2021 Dec 1; 523: 476-482.

Background And AimsMonitoring the immune response against SARS-CoV-2 is pivotal in the evaluation of long-term vaccine efficacy. Immunoglobulin G (IgG) antibodies represent an advisable tool to reach this goal, especially for the still poorly defined antibody trend induced by the new class of mRNA vaccines against SARS-CoV-2.Materials And MethodsAnti-Spike RBD IgG antibodies were monitored in a cohort of healthcare workers at CRO Aviano, National Cancer Institute, through MAGLUMI® chemiluminescence assay, at 1 and 4 months after full-schedule of BNT162b2 or mRNA-1273 vaccination.ResultsAt 1 month after vaccination, 99.9% of 767 healthcare workers showed a reactive antibody response, which was inversely correlated with age, and positively associated with a previous history of COVID-19, and mRNA-1273 vaccination. Serological response was maintained in 99.6% of the 516 subjects monitored also at follow-up. An antibody decay from 559.8 AU/mL (IQR 359.7-845.7) to 92.7 AU/mL (IQR 65.1-148.6; p < 0.001) was observed, independently from age and sex.ConclusionOur data supported the ability of SARS-CoV-2 mRNA vaccines to induce at least a 4 months-lasting IgG response, even outside the rules of clinical trials. The antibody decay observed at follow-up suggested to deepen the immune response characterization to identify subjects with low anti-SARS-CoV-2 immunity possibly requiring a vaccination boost.Copyright © 2021 Elsevier B.V. All rights reserved.

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