• J. Inorg. Biochem. · Dec 2021

    Review

    Zinc ionophores: chemistry and biological applications.

    • Simone Scavo and Valentina Oliveri.
    • Dipartimento di Scienze Chimiche, Università degli Studi di Catania, v.le A. Doria 6, 95125 Catania, Italy.
    • J. Inorg. Biochem. 2021 Dec 9; 228: 111691.

    AbstractZinc can play a pathophysiological role in several diseases and can interfere in key processes of microbial growth. This evidence justifies the efforts in applying Zinc ionophores to restore Zinc homeostasis and treat bacterial/viral infections such as coronavirus diseases. Zinc ionophores increase the intracellular concentration of Zinc ions causing significant biological effects. This review provides, for the first time, an overview of the applications of the main Zinc ionophores in Zinc deficiency, infectious diseases, and in cancer, discussing the pharmacological and coordination properties of the Zinc ionophores.Copyright © 2021 Elsevier Inc. All rights reserved.

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