• Keibun Liu, Kensuke Nakamura, Hajime Katsukawa, Peter Nydahl, Eugene Wesley Ely, Sapna R Kudchadkar, Kunihiko Takahashi, Muhammed Elhadi, Mohan Gurjar, Be Kim Leong, Chi Ryang Chung, Jayachandran Balachandran, Shigeaki Inoue, Alan Kawarai Lefor, and Osamu Nishida.
• Critical Care Research Group, Faculty of Medicine, The Prince Charles Hospital, University of Queensland, Brisbane, QLD, Australia.
• Front Med (Lausanne). 2021 Jan 1; 8: 735860.

AbstractBackground: Data regarding delivery of evidence-based care to critically ill patients in Intensive Care Units (ICU) during the COVID-19 pandemic is crucial but lacking. This study aimed to evaluate the implementation rate of the ABCDEF bundle, which is a collection of six evidence-based ICU care initiatives which are strongly recommended to be incorporated into clinical practice, and ICU diaries for patients with and without COVID-19 infections in ICUs, and to analyze the impact of COVID-19 on implementation of each element of the bundle and independent associated factors. Methods: A world-wide 1-day point prevalence study investigated the delivery of the ABCDEF bundle and ICU diary to patients without or with COVID-19 infections on 27 January 2021 via an online questionnaire. Multivariable logistic regression analysis with adjustment for patient demographics evaluated the impact of COVID-19 and identified factors in ICU administrative structures and policies independently associated with delivery. Results: From 54 countries and 135 ICUs, 1,229 patients were eligible, and 607 (49%) had COVID-19 infections. Implementation rates were: entire bundle (without COVID-19: 0% and with COVID-19: 1%), Element A (regular pain assessment: 64 and 55%), Element B (both spontaneous awakening and breathing trials: 17 and 10%), Element C (regular sedation assessment: 45 and 61%), Element D (regular delirium assessment: 39 and 35%), Element E (exercise: 22 and 25%), Element F (family engagement/empowerment: 16 and 30%), and ICU diary (17 and 21%). The presence of COVID-19 was not associated with failure to implement individual elements. Independently associated factors for each element in common between the two groups included presence of a specific written protocol, application of a target/goal, and tele-ICU management. A lower income status country and a 3:1 nurse-patient ratio were significantly associated with non-implementation of elements A, C, and D, while a lower income status country was also associated with implementation of element F. Conclusions: Regardless of COVID-19 infection status, implementation rates for the ABCDEF bundle, for each element individually and an ICU diary were extremely low for patients without and with COVID-19 infections during the pandemic. Strategies to facilitate implementation of and adherence to the complete ABCDEF bundle should be optimized and addressed based on unit-specific barriers and facilitators.Copyright © 2021 Liu, Nakamura, Katsukawa, Nydahl, Ely, Kudchadkar, Takahashi, Elhadi, Gurjar, Leong, Chung, Balachandran, Inoue, Lefor and Nishida.

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