• Internal medicine · Jul 2022

    Case Reports

    Successful Treatment of Antibody-mediated Pure Red Cell Aplasia Induced by Continuous Erythropoietin Receptor Activator with Prednisolone.

    • Nozomi Okahashi, Masayuki Kubo, Ei Hoshino, Masahito Uchihara, Itsuto Amano, and Haruyuki Tanaka.
    • Department of Internal Medicine, Saiseikai Chuwa Hospital, Japan.
    • Intern. Med. 2022 Jul 15; 61 (14): 2209-2213.

    AbstractPure red cell aplasia (PRCA) associated with erythropoiesis-stimulating agents (ESAs), which were first reported in 1998, usually occurs with subcutaneous administration of epoetin alfa (Eprex®). Improvements in ESA storage, handling, and administration methods have reduced the PRCA incidence. Continuous erythropoietin receptor activator (CERA) is a third-generation ESA that is rarely reported to induce PRCA. We herein report a case of CERA-induced PRCA presenting with positive anti-erythropoietin (EPO) and anti-CERA antibodies, which was successfully treated with prednisolone. Clinicians should be aware of the possibility of antibody-mediated PRCA induced by an ESA in CKD patients with anemia with reticulocytopenia and low serum EPO levels.

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