• Shinji Izuka, Toshihiko Komai, Bunki Natsumoto, Hirofumi Shoda, and Keishi Fujio.
• Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Japan.
• Intern. Med. 2022 Mar 15; 61 (6): 903-906.

AbstractPolymyalgia rheumatica (PMR) is an inflammatory rheumatic disease characterized by stiffness and aching mainly in the shoulders, neck and hip girdles. The underlying pathogenesis of PMR involves myeloid lineage activation with a high expression of pattern recognition receptors. In addition, vaccination against severe acute respiratory syndrome coronavirus 2 with mRNA-1273 functions as both an immunogen and intrinsic adjuvant. It leads to the activation of innate immunity, resulting in antibody production. We herein report the first case of PMR-like syndrome seven days after mRNA-1273 vaccination. Reassuringly, the symptoms, such as pain of the neck, shoulder girdle and pelvic girdle, as well as elevated inflammatory markers were resolved within a month without glucocorticoid or immunosuppressant administration.

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