• Cell host & microbe · Jun 2018

    Review

    Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease.

    • Allison Agus, Julien Planchais, and Harry Sokol.
    • INRA, UMR1319 Micalis & AgroParisTech, Jouy en Josas, France.
    • Cell Host Microbe. 2018 Jun 13; 23 (6): 716-724.

    AbstractThe gut microbiota is a crucial actor in human physiology. Many of these effects are mediated by metabolites that are either produced by the microbes or derived from the transformation of environmental or host molecules. Among the array of metabolites at the interface between these microorganisms and the host is the essential aromatic amino acid tryptophan (Trp). In the gut, the three major Trp metabolism pathways leading to serotonin (5-hydroxytryptamine), kynurenine (Kyn), and indole derivatives are under the direct or indirect control of the microbiota. In this review, we gather the most recent advances concerning the central role of Trp metabolism in microbiota-host crosstalk in health and disease. Deciphering the complex equilibrium between these pathways will facilitate a better understanding of the pathogenesis of human diseases and open therapeutic opportunities.Copyright © 2018 Elsevier Inc. All rights reserved.

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