• Takao Imanishi, Masahiro Hasegawa, and Akihiro Sudo.
• Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
• Arch Orthop Trauma Surg. 2010 Dec 1; 130 (12): 1447-50.

IntroductionMetal-on-metal bearings for total hip arthroplasty are increasing in popularity. However, metal ion toxicity, metal hypersensitivity, and metal carcinogenicity are the causes concern for patients with metal-on-metal hip replacement. We investigated serum levels of cobalt and chromium ions in patients with successfully implanted second-generation metal-on-metal total hip arthroplasty (THA) using PINNACLE-A (DePuy, Warsaw, IN, USA).Materials And MethodsThirty-three patients underwent primary cementless THA with the use of a 36-mm femoral head PINNACLE-A with a metal-on-metal articulation. Blood samples were taken preoperatively, at 3 months, and at 1 year, and levels of cobalt and chromium were determined.ResultsAt 3 months, levels of both cobalt and chromium had increased significantly compared with preoperative levels. There were no significant differences between levels of either metal at 3 months and 1 year.ConclusionPatients with metal-on-metal THA had higher circulating levels of metal ions than before arthroplasty at 3 months, with no additional significant increases at 1 year in this study.

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