• Erdinc Gulumsek, Hilmi Erdem Sumbul, Fatih Yesildal, Cisem Kizildag, Dilan Damla Ozturk, Begum Seyda Avci, Beytullah Aktas, Akkan Avci, Edip Bayrak, Adnan Tas, and Banu Kara.
• Department of Gastroenterology, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey.
• Ir J Med Sci. 2022 Jun 1; 191 (3): 1171-1176.

BackgroundIn ulcerative colitis patients, Elabela levels and the relation of Elabela with laboratory parameters is unknown.AimThe purpose of this study was to investigate the serum Elabela levels in UC patients and its relationship with other clinical and laboratory findings.MethodsForty-three patients with UC and 40 healthy controls (group I) similar in age and gender were included in the study. Routine patient history, physical examination, and laboratory tests were followed by analysis of serum Elabela levels. Endoscopic activity index (EAI) of patients with UC was calculated. There were two groups of patients: those in remission (group II) and with active disease (group III).ResultsGroups I, II, and III had 40, 22, and 21 participants, respectively. Serum Elabela levels were found to be 3.32 ± 1.25 ng/mL in group I, 3.38 ± 0.88 ng/mL in group II, and 5.48 ± 1.61 ng/mL in group III. Comparing the serum Elabela levels, a statistically significant difference was found between three groups (p < 0.001). Serum Elabela level showed a significant and positive correlation with EAI, leukocyte count, and hs-CRP, while a negative correlation was found with hemoglobin levels in univariate analysis (p < 0.001, for each). In linear regression analysis, these parameters were found to be associated with EAI and hs-CRP (p = 0.049, β = 0.337, and p = 0.015, β = 0.396, respectively).ConclusionElabela concentrations in patients with active UC was significantly higher and was associated with EAI and hs-CRP. Blood Elabela concentrations can be useful in the diagnosis and follow-up of patients with active UC.© 2022. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.

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