• Marco Ulises Martínez-Martínez, Deshiré Alpízar-Rodríguez, Rogelio Flores-Ramírez, Diana Patricia Portales-Pérez, Ruth Elena Soria-Guerra, Francisco Pérez-Vázquez, and Fidel Martinez-Gutierrez.
• Hospital General de Subzona No. 9, Instituto Mexicano del Seguro Social, Fray Juan Bautista de Mollinedo No 26, Rioverde, San Luis Potosí, Mexico. marcomtzmtz@hotmail.com.
• J Gen Intern Med. 2022 Feb 1; 37 (3): 624-631.

BackgroundCoronavirus disease 2019 (COVID-19) causes a mild illness in most cases; forecasting COVID-19-associated mortality and the demand for hospital beds and ventilators are crucial for rationing countries' resources.ObjectiveTo evaluate factors associated with the severity of COVID-19 in Mexico and to develop and validate a score to predict severity in patients with COVID-19 infection in Mexico.DesignRetrospective cohort.ParticipantsWe included 1,435,316 patients with COVID-19 included before the first vaccine application in Mexico; 725,289 (50.5%) were men; patient's mean age (standard deviation (SD)) was 43.9 (16.9) years; 21.7% of patients were considered severe COVID-19 because they were hospitalized, died or both.Main MeasuresWe assessed demographic variables, smoking status, pregnancy, and comorbidities. Backward selection of variables was used to derive and validate a model to predict the severity of COVID-19.Key ResultsWe developed a logistic regression model with 14 main variables, splines, and interactions that may predict the probability of COVID-19 severity (area under the curve for the validation cohort = 82.4%).ConclusionsWe developed a new model able to predict the severity of COVID-19 in Mexican patients. This model could be helpful in epidemiology and medical decisions.© 2021. Society of General Internal Medicine.

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