• Medicina clinica · Sep 2022

    Cardiac amyloidosis: Description of a series of 143 cases.

    • Gonzalo Barge-Caballero, Eduardo Barge-Caballero, Manuel López-Pérez, Raquel Bilbao-Quesada, Eva González-Babarro, Inés Gómez-Otero, Andrea López-López, Mario Gutiérrez-Feijoo, Alfonso Varela-Román, Carlos González-Juanatey, Óscar Díaz-Castro, and María G Crespo-Leiro.
    • Complexo Hospitalario Universitario de A Coruña (CHUAC), Servicio Galego de Saúde (SERGAS), Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, España; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, España. Electronic address: gonzalo.barge.caballero@sergas.es.
    • Med Clin (Barc). 2022 Sep 9; 159 (5): 207-213.

    Introduction And ObjectivesRecently, there have been important advances in the diagnosis and treatment of cardiac amyloidosis (CA). Our aim was to provide an updated description of its 2 most frequent types: the transthyretin CA (ATTR-CA) and the light chain CA (AL-CA).MethodsProspective registry of patients with CA diagnosed in 7 institutions in Galicia (Spain) between January 1, 2018 and June 30, 2020. Variables related to clinical characteristics, complementary tests, survival and causes of death were collected.ResultsOne hundred and forty-three patients with CA were consecutively included, 128 ATTR-CA (89.5%) and 15 AL-CA (10.5%). Mean age was 79.6±7.7 years and 23.8% were women. Most patients with ATTR-CA were diagnosed non-invasively (87.5%). On physical examination, 35.7, 35 and 7% had Popeye's sign, Dupuytren's contracture and macroglossia, respectively. Twelve-month and 24-month survival was 92.1 and 76.2% in the ATTR-CA group, and 78.6 and 61.1% in the AL-CA group (P=.152). The cause of death was cardiovascular in 80.8% of the cohort.ConclusionsATTR-CA can be diagnosed non-invasively in most cases and it is the most common type of CA in routine clinical practice. Furthermore, an increase in the short-term survival of CA appears to be observed, which could be due to advances related to its diagnosis and treatment.Copyright © 2021 Elsevier España, S.L.U. All rights reserved.

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