• Yang Chen, Fei Huang, Youwen Fan, Dong Li, Qiang Tao, Di Tang, Liang Deng, and Chao Ma.
• Department of General Surgery, The Seventh Affiliated Hospital of Sun Yat-Sen University (ShenZhen), Shen Zhen, China.
• Am. J. Med. Sci. 2022 Jun 1; 363 (6): 511-518.

BackgroundEndoscopic ultrasound (EUS) is widely used as a cost-effective method for detecting pancreatic neuroendocrine tumors (PNTs), but its diagnostic value is variable among published studies. This meta-analysis aimed to determine the diagnostic value of EUS for PNTs.MethodsThree electronic databases, including PubMed, Embase, and the Cochrane Library, were searched for studies published up to July 2018. The summary sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and receiver operating characteristic (ROC) curve were calculated to evaluate the diagnostic value of EUS using the random-effects model.ResultsThirteen studies involving 609 patients were included in this meta-analysis. The summary sensitivity and specificity of EUS for detecting PNTs were 0.86 and 0.89, respectively. The PLR and NLR of EUS were 7.81 and 0.15, respectively. The DOR of EUS for diagnosing PNTs was 24.20. The area under the ROC was 0.90. Finally, the subgroup analyses indicated that publication year and percentage of males could introduce potential biases for the DOR of EUS.ConclusionsThis meta-analysis suggests that EUS has a relatively high diagnostic value for diagnosing PNTs.Copyright © 2022 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

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