• Morteza Hashemian, Alireza Mirkheshti, Amirhossein Mirafzal, Habibeh Ahmadipour, and Mohammad Amirhosseini Nasehabad.
• Department of Anesthesiology and Pain Medicine, Kerman University of Medical Sciences, Kerman, Iran. Mortezahashemian@kmu.ac.ir.
• Ir J Med Sci. 2022 Dec 1; 191 (6): 271127162711-2716.

BackgroundMagnesium sulfate has been reported to be effective in perioperative pain treatment and in blunting somatic, autonomic, and endocrine reflexes provoked by noxious stimuli. The pre-emptive analgesic effects of magnesium in reducing postoperative pain could be beneficial in abdominal and gynecologic surgeries.ObjectiveThe aim of study was to compare the pre-emptive analgesic effects of oral magnesium oxide and naproxen for hysterectomy surgery.MethodsThis study evaluated all patients who were candidates for hysterectomy in 2 months. The 64 patients were randomly divided into two groups using a random allocation sequence. The patients in the intervention and control groups received either magnesium oxide tablet (500 mg) or naproxen tablet (500 mg) orally half an hour before surgery, respectively. The severity of postoperative pain is assumed as a primary outcome which is evaluated using the visual analogue scale (VAS).ResultsIn this study, 64 patients were assessed. The results showed age, weight, systolic and diastolic blood pressure, and pulse rate of the patients in the two groups were not significantly different (p > 0.05). The mean score of pain intensity for these patients was significantly lower than the patients receiving naproxen (p-value: 0.03). Besides, more than one-quarter of patients in the magnesium oxide group (n = 9, 28.12%) received this analgesia with lower dose than the patients in the naproxen group (p-value: 0.03).ConclusionThe results of this study showed that preoperative oral magnesium oxide had a significant effect on the severity of postoperative pain and consumption of postoperative analgesia.© 2022. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.

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