• Margaret H Sandham, Emma A Hedgecock, Richard J Siegert, Ajit Narayanan, Mevhibe B Hocaoglu, and Irene J Higginson.
• School of Clinical Sciences (M.S., R.S.), Auckland University of Technology, Auckland, New Zealand. Electronic address: Margaret.sandham@aut.ac.nz.
• J Pain Symptom Manage. 2022 May 1; 63 (5): 747-757.

ContextThe growth of patient reported outcome measures data in palliative care provides an opportunity for machine learning to identify patterns in patient responses signifying different phases of illness.ObjectivesThe study will explore if machine learning and network analysis can identify phases in patient palliative status through symptoms reported on the Integrated Palliative Care Outcome Scale (IPOS).MethodsA partly cross-sectional and partially longitudinal observational study was undertaken using the Australasian Karnofsky Performance Scale (AKPS); Integrated Palliative Care Outcome Scale (IPOS); Phase of Illness (POI). Patient palliative records (n = 1507, 65% stable, 20% unstable, 9% deteriorating, 2% terminal) from 804 adult patients enrolled in a New Zealand palliative care service were analysed using a combination of statistical, machine learning and network analysis techniques.ResultsData from IPOS showed considerable variation with phase. Also, network analysis showed clear associations between items by phase. Six machine learning techniques identified the most important variables for predicting possible transition between phases of illness. Network analysis for all patients showed that Poor Appetite and Loss of Energy were central IPOS items, with Loss of Energy linked to Drowsiness, Shortness of Breath and Lack of Mobility on the one hand, and Poor Appetite linked to Nausea, Vomiting, Constipation and Sore and Dry Mouth on the other.ConclusionThese preliminary results, when coupled with the latest technological developments in mobile apps and wearable technology, could point the way to increased use of digital therapeutics in continuous palliative care monitoring.Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

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