• Rev Med Interne · Mar 2022

    Case Reports

    [Fish odor syndrome: A socially disabling disorder].

    • S Nicolas, H Blasco, A Bigot, N Tressel, B Hennart, and F Maillot.
    • Service de médecine interne, CHRU de Tours, Tours, France; Université de Tours, Tours, France.
    • Rev Med Interne. 2022 Mar 1; 43 (3): 178-180.

    IntroductionFish odor syndrome (FOS) is a rare metabolic disorder that manifests as "rotten fish" body odor and is caused by the excretion of trimethylamine (TMA) in body fluids. This disease can have a negative impact on the social life of affected patients.Case ReportsWe report the case of two female patients complaining about unpleasant body odor. The diagnosis of FOS was confirmed by the demonstration of trimethylaminuria by NMR spectroscopy and by molecular analysis of the FMO3 gene. A restrictive choline diet combined with digestive decontamination reduced odor symptoms and improved the social life of these 2 patients.ConclusionsFish odor syndrome is a rare and unrecognized disease that can affect the quality of life of affected persons. Following laboratory diagnosis, treatment is often effective.Copyright © 2022 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

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